ASCAP is a malignant tumor with debatable histogenesis.
We report the case of a year-old man, with a history of more than half of a year of right upper quadrant abdominal pain, jaundice, with no anamnestic data of acute or chronic pancreatitis, or substance abuse.
On gross examination the tumor was solid, white, poorly circumscribed, located in the head of the pancreas, with 4 cm diameter, and direct extension into cancer pancreatic head of Vater, common bile duct, and peripancreatic soft tissue.
Microscopically, the tumor was composed of squamous polygonal cells arranged in small glandular structures, with tightly packed pattern, and mild nuclear pleomorphism, along with small areas with Alcian blue positive intracellular mucin. Therefore, the differential diagnosis between ASCAP and pancreatic collision tumor, metastasis of adenosquamous carcinoma or mucoepidermoid tumor was compulsory.
The immuno-histochemistry assay confirmed ASCAP as the final diagnosis, based on the intense positive reaction for cytokeratin 7 mainly in the glandular structures, whereas cytokeratin 5 and p63 were positive predominantly in the squamous component. The present report aimed to highlight the pathological characteristics of this rare subtype of pancreatic tumors and to point out the difficulty in differentiation between a pancreatic and an extra pancreatic biliary tract or ampulla of Vater tumor, due to the extensive tumor growth that interests, in advanced stages, the same anatomical space, given the different prognosis and therapeutic approach of these entities.
Specialiștii au descoperit un nou mod prin care să diagnosticheze cancerul de pancreas, după tipologia microbilor de pe limbă. Cancerul pancreatic este de obicei o formă agresivă de cancer, cu o rată de supraviețuire destul de mică. Acest fapt se datorează și diagnosticării târzii, în lipsa apariției simptomelor.
Adenosquamous carcinoma of the pancreas. Digestion ; 72 : Adenosquamous Carcinoma of the Pancreas, Arch Surg. Herxheimer G. Uber heterologe Cancroide.
Had to defer the case on an end-stage Pancreatic Ca. A trebuit să amân un caz de cancer pancreatic.
Beitr Pathol Anat ; J Surg Res ; 1 : Cancer ; Makiyama K, et al. J Gastroenterol ; Hsu JT, et al. Clinicopathologic features and cancer pancreatic head following surgery for pancreatic adenosqua-mous carcinoma, World J Surg Oncol ; 6: Nabae T, et al.
Adenosquamous carcinoma of the pancreas: report of two cases, Am J Gastroenterol. Okabayashi T, Hanazaki K. Surgical outcome of adenosquamous carcinoma of the pancreas.
World J Gastroenterol ; 14 44 :
About Dragi prieteni, Cu inima franta va anunt ca Liana Bazaru, in varsta de 47 ani, a fost diagnosticata in Romania, cu cancer pancreatic in data de 24 februarie. In Romania, pacientii cu acest diagnostic, din pacate, au o speranta de viata foarte scurta, pentru ca nu exista protocol oncologic pentru acest tip de cancer.